A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy
نویسندگان
چکیده
Abstract Background PD-1 checkpoint inhibitors are novel therapeutic agents in colorectal cancer (CRC). Immunohistochemical staining for CD274 assessment is standardised upper GI cancer, but not CRC. Methods Methodologies of relevant studies were scrutinized and meta-analysis survival CD274/PDCD1 performed. Furthermore, anti-PD-1 therapy clinical trial results CRC assessed with particular emphasis on assessment. Results 24 included. immune cells was associated good prognosis. tumour has heterogenous outcomes does meet requirements a prognostic marker. As marker response to therapy, Conclusion appear useful as methodology requires standardisation. the Combined Positive Score (CPS) used this seems logical method adopt. Thresholds remain be determined.
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CD274 (PD-L1)-Expression in colorectal cancer
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ژورنال
عنوان ژورنال: Critical Reviews in Oncology Hematology
سال: 2021
ISSN: ['1879-0461', '1040-8428']
DOI: https://doi.org/10.1016/j.critrevonc.2020.103147